Vaccines are a powerful measure to protect the health of individuals and to combat outbreaks such as the COVID-19 pandemic. An ethical dilemma arises when one effective vaccine has been successfully developed against an epidemic disease and researchers seek to test the efficacy of another vaccine for the same pathogen in clinical trials involving human subjects. On the one hand, there are compelling reasons why it would be unethical to trial a novel vaccine when an effective product exists already. First, (...) it is a firm principle of medical ethics that an effective treatment or vaccine should not be withheld from patients if their life may depend on it. Second, since epidemic outbreaks often emerge in settings with less-resourced health systems, there is a pronounced risk that any trial withholding an effective vaccine would disproportionately affect the vulnerable populations that historically have been exploited for biomedical research. Third, clinical trials for novel vaccines may be at odds with efforts to control active outbreaks. On the other hand, it may be justified to conduct a trial for a candidate vaccine if it is expected to have certain advantages compared with the existing product. This essay discusses key factors for comparing vaccines against epidemic pathogens, including immunological, logistical and economic considerations. Alongside a case study of the development of vaccines for Ebola, the essay seeks to establish a general framework that should be expanded and populated by immunologists, epidemiologists, economists and bioethicists, and ultimately could be applied to the case of COVID-19 vaccines. (shrink)

The volume documents, and makes an original contribution to, an astonishing period in twentieth-century philosophy—the progress of Arne Naess's ecophilosophy from its inception to the present. It includes Naess's most crucial polemics with leading thinkers, drawn from sources as diverse as scholarly articles, correspondence, TV interviews and unpublished exchanges. The book testifies to the skeptical and self-correcting aspects of Naess's vision, which has deepened and broadened to include third world and feminist perspectives. Philosophical Dialogues is an essential addition to the (...) literature on environmental philosophy. (shrink)

The Danish marine biologist Anton Frederik Bruun (1901–1961) is chiefly remembered as an explorer of the deep-sea fauna and a key figure in international scientific organizations during the 1950s. As the Cold War increasingly permeated the marine sciences and it became too expensive for small states to operate deep-sea research vessels, he became an asset to the USA's oceanographic establishment as it sought to first assess Soviet strength (in terms of research, technology and logistical capacity) and then to build up (...) American oceanography in response. Bruun's contacts with the USSR – including a visit in 1957 – strengthened his contacts to the American military as well as American oceanographers. His enthusiasm for raising interest in the marine sciences in developing countries could also be matched to American geopolitical goals. Bruun's participation in the Scripps Institution of Oceanography's Naga expedition to the South China Sea and Gulf of Thailand captured the mutually beneficial nature of his American connections. Bruun was able to use the USA to reach distant oceans, while the USA in turn gained from Bruun's prestige as it forged connections with friendly states through science, an increasingly important arena for Cold War competition. (shrink)

ZUSAMMENFASSUNGDie Kirche sieht sich in der Zuständigkeit für die Verwaltung des Transzendenten. Gestützt auf die Genesis erhebt sie aber auch den Erklärungsanspruch für die Entstehung der irdischen Welt. Jedoch weicht sie hier mehr und mehr der naturwissenschaftlichen Konkurrenz. Selbst die Evolutionstheorie wird heute nicht mehr rundweg abgelehnt. Die Neubewertung des Realitäts-begriffs und der Naturgesetze durch die evolutionäre Erkenntnistheorie zeigt jedoch, dass auch der Erklärungsanspruch empirischer Weltbilder überdacht werden muss, was nicht ohne Einfluss auf das Verhältnis zu den religiösen Weltbildern bleibt.Viel (...) gravierender jedoch kann die Tendenz werden, dass sich die Auseinandersetzung zwischen Religion und Wissenschaften immer mehr von den Naturwissenschaften zu den Sozialwissenschaften verlagert. Probleme der physischen Naturbeherrschung sind heute sehr viel weiter gehend gelöst als die Probleme der sozialen Umwelt. Schon heute ist das zentrale Paradigma der Menschheit die Bewältigung sozialer Probleme. Die Beherrschung des Klimas zum Beispiel, von der Sache her ein physisches Problem, wird mehr und mehr zum sozialen Problem. Wollen die Kirchen hier als gestaltende Kraft mithalten, müssen sie sich von der auf die Bibel gestützten Angebotsorientierung fortentwickeln zu der Nachfrageorientierung politischer Parteien und anderer Sozialorganisationen. Das könnte sich zur Bedrohung der theologischen Bedeutung der Kirchen entwickeln. SUMMARYThe church sees itself as the general administrator of the transcendent. But at the same time, based on the genesis, it claims as well the competence to explain the creation of the physical world. Here, however, it recoils more and more from the natural sciences. Even the idea of biological evolution is no longer flatly rejected. However, the reinterpretation of the natural laws and the notion of reality within the framework of the evolutionary epistemology show that the explanatory power of the natural sciences is no longer unquestionable. This, no doubt, has consequences for the relationship of natural and transcendental sciences.Of far more impact, however, can be the trend that the dispute between religion and sciences is shifting from the nature sciences towards the social sciences. Problems we have with our natural environment and to be solved by nature sciences are replaced more and more by problems we have with our social environment and to be solved by the social sciences. Already nowadays the central paradigm of mankind is the solution of social problems. Mastering the climate, for example, though primarily a physical problem becomes more and more a social subject. If the churches want to keep up here they have to shift from the supply orientation as provided by the bible towards the demand orientation presented by political and other social organisations. This could begin to threaten the theological importance of the churches. (shrink)

Kierkegaard's ambiguous aesthetics -- Becoming Christian -- Christ and the art of subjective becoming -- Mimesis, aesthetics, and Christian becoming -- Becoming amidst the existence stages -- Becoming and art.

This paper tries to combine Peirce’s cosmology and metaphysics with current understanding in physics of the evolution of the universe, regarded as an ongoing semiotic process in a living cosmos. While the basic property of Life is viewed as an unexplainable Firstness inherent in the initial iconic state of the vacuous continuum we shall consider and exemplify two sign developing processes: (a) the transition from icon to index is considered as a symmetry breaking emergence of order actualising one among the (...) possibilities of the iconic vacuum; (b) the transition from index to symbol, regarded as a habit formation — an adaptation of the surroundings to the order that has emerged. While the iconic state is characterized by fractal self-similarity the transitions to index and symbol are modelled by the mean field theory of second order phase transitions. (shrink)

Although Lorenz Oken is a classic example of Naturphilosophie as applied to biology, his views have been imperfectly understood. He is best viewed as a follower of Schelling who consistently attempted to apply Schelling's ideas to biological data. His version of Naturphilosophie, however, was strongly influenced by older pseudoscience traditions, especially alchemy and numerology as they had been presented by Robert Fludd, whose works were current in Jena and available to him. According to those influences, parts of Oken's philosophical conception (...) were communicable even in a non-idealistic scientific culture, for example in Paris, where Oken met Étienne Geoffroy Saint-Hilaire. Geoffroy however was embedded in a French intellectual tradition, and the correspondence between his views and those of Oken was only superficial. The English anatomist Richard Owen attempted to incorporate the views of Oken and Geoffroy within his own, idiosyncratic system. Although Darwin knew of Oken's ideas, it was Geoffroy who really affected his evolutionary biology, and any influence of Oken must have been attenuated to the point of triviality. (shrink)

Retinopathy of prematurity (ROP) is a complex neonatal disorder with multiple contributing factors. In this paper we have mounted the evidence in support of the proposal that neonatal sepsis meets all requirements for being a cause of ROP (not a condition, mechanism, or even innocent bystander) by means of initiating the early stages of the pathomechanism of ROP occurrence, systemic inflammation. We use the model of etiological explanation, which distinguishes between two overlapping processes in ROP causation. It can be shown (...) that sepsis can initiate the early stages of the pathomechanism via systemic inflammation (causation process) and that systemic inflammation can contribute to growth factor aberrations and the retinal characteristics of ROP (disease process). The combined contribution of these factors with immaturity at birth (as intrinsic risk modifier) and prenatal inflammation (as extrinsic facilitator) seems to provide a cogent functional framework of ROP occurrence. Finally, we apply the Bradford Hill heuristics to the available evidence. Taken together, the above suggests that neonatal sepsis is a causal inducer of ROP. (shrink)

Buckminster Fuller’s experiences in the Navy became a model for his ecological design projects and suggestions for the global management of ‘Spaceship Earth’. Inspired by technocratic ideas of the 1930s, Fuller envisaged, in the 1970s, an elitist world without politics, in which designers were at the helm, steering the planet out of its environmental crises.

Sixteen essays examine the use of evidence in culture, media, and science communication, ranging from paleontology, meteorology, neurological science/computation to literature, film, photography, and civic rhetoric. In full color.

It is generally assumed that electronic cryptography benefits democracy because it can be instrumental in protecting free speech, which is considered a cornerstone for democracy. The author argues, however, that a close look at some aspects of democratic theory suggests that matters are not really as clear-cut. The fact that encryption can be abused in many ways also poses a threat to democracy. This paradox is examined in detail.

In this essay, I argue that Ted Poston's theory of explanatory coherentism is well-suited as a tool for causal explanation in the health sciences, particularly in epidemiology. Coherence has not only played a role in epidemiology for more than half a century as one of Hill's viewpoints, it can also provide background theory for the development of explanatory systems by integrating epidemiologic evidence with a diversity of other error-independent data. I propose that computational formalization of Hill's viewpoints in an explanatory (...) coherentist framework would provide an excellent starting point for a formal epistemological (knowledge-theoretical) project designed to improve causal explanation in the health sciences. As an example, I briefly introduce Paul Thagard's ECHO system and offer my responses to possible objections to my proposal. (shrink)

Are we perhaps in the "matrix", or anyway, victims of perfect and permanent computer simulation? No. The most convincing—and shortest—version of Putnam's argument against the possibility of our eternal envattment is due to Crispin Wright (1994). It avoids most of the misunderstandings that have been elicited by Putnam's original presentation of the argument in "Reason, Truth and History" (1981). But it is still open to the charge of question-begging. True enough, the premisses of the argument (disquotation and externalism) can be (...) formulated and defended without presupposing external objects whose existence appears doubtful in the light of the very skeptical scenario which Putnam wants to repudiate. However, the argument is only valid if we add an extra premiss as to the existence of some external objects. In order to avoid circularity, we should run the argument with external objects which must exist even if we are brains in a vat, e.g. with computers rather than with trees. As long as the skeptic is engaged in a discussion of the brain-in-a-vat scenario, she should neither deny the existence of computers nor the existence of causal relations; for if she does, she is in fact denying that we are brains in a vat. (shrink)

In this article the authors focus on the emergence, or disappearance, of notions of responsibility in social dynamic processes. Hence, the starting point in this article is concrete behavior within organisational settings. This article presents a systematic overview of mechanisms related to acting upon a sense of moral responsibility. Some of these mechanisms are based on individual characteristics, others are embedded in the social context wherein responsible behaviour emerges or disappears. In this article, various mechanisms are identified and labelled in (...) order to analyse what types of processes are behind the mechanisms. In this way, the article yields important understandings for the conscious use of these mechanisms to strengthen responsible behavior within organisations. (shrink)

Als Goethe in seiner monumentalen Farbenlehre einen Angriff auf Newtons Theorie des Lichts und der Farben lancierte, setzte er eine Methode ein, die er als Vermannigfachung der Erfahrungen bezeichnete: Er variierte verschiedene Parameter der newtonischen Experimente, um neuen Spielraum für Alternativen zur Theorie Newtons zu gewinnen. Dabei erzielte er durchaus Erfolge. U.a. entdeckte er das Komplement zum newtonischen Spektrum (das aussieht wie dessen Farbnegativ und durch Vertauschung der Rollen von Licht und Finsternis entsteht). Kürzlich hat der Wiener Maler Ingo Nussbaumer (...) Goethes Methode kongenial fortgeführt. Dabei hat er sechs weitere Farbspektren entdeckt. Sie entstehen, wenn man anstelle des Hell/Dunkel-Kontrasts (in Newtons und Goethes Experimenten) mit Paaren bunter Komplementärfarben arbeitet. Die neuen Farbspektren sehen genauso differenziert aus wie Newtons und Goethes Spektrum; doch anders als diese enthalten sie die unbunten "Farben" Schwarz und Weiß. Die vielfältigen Ordnungsbeziehungen und Symmetrien, die Ingo Nussbaumer in der Farbenwelt der insgesamt acht Spektren ausgemacht hat, verhelfen uns vielleicht zu einem tieferen Verständnis der Prinzipien menschlicher Farbwahrnehmung. Und sie tauchen die überkommenen Prinzipien der additiven und der subtraktiven Farbmischung in neues Licht. (shrink)

Rarely does research in the history and philosophy of science lead to new empirical results, but that is exactly what has happened in one of the essays of this special issue: Rang and Grebe-Ellis have developed new experimental techniques to perform measurements Goethe proposed 217 years ago. These measurements fit neatly with Goethe’s idea of polarity—his complementary spectrum is not only an optical, but also a thermodynamical counterpart of Newton’s spectrum. I use the new measurements, firstly, to argue against the (...) asymmetries between light and darkness posited by Lyre and Schreiber; and, secondly, to explicate the alternative theory that Goethe had introduced to urge scientific pluralism. In my replies to exegetical criticism by Böhler, Hampe and Zemplén, I show that the main goal of Goethe’s Farbenlehre was indeed to expose symmetries between light and darkness. Furthermore, I argue that it is worthwhile to focus on the experiments, arguments and hypotheses of the Farbenlehre, and not merely on rhetorical, narrative or stylistical aspects, as Böhler and Hampe would have it. Goethe’s criticism of Newton is often dismissed, but it is in fact surprisingly relevant today. (shrink)

The aim of this paper is to reconcile the two modes of description of macrosystems, i.e., to remove certain inconsistencies between the classical phenomenological and the quantum-theoretical descriptions of a macrosystem. Starting from Ludwig's formulation of a general framework for classical theories and his ansatz for a compatibility condition between the quantum theoretical and the classical mode of description for a macrosystem, we try to make clear what the “classical content” of many-body quantum theory really is. It is shown that (...) this classical content may be described by a certain “observable,” i.e., an operator-valued measure over the Borel sets of the classical trajectory space. There exists a reduced time evolution within this classical content which has the structure of a true semigroup in case of an irreversible classical time evolution. (shrink)

This volume contains a collection of 17 essays on Philo written by Peder Borgen between 1987 and 2018. The first six studies deal with important issues in Philo's religious thought and social world, such as his views on Flaccus, prayers, and his eschatology. The next five essays illustrate how an understanding of Philo can contribute to the interpretation of Paul, especially his Letter to the Galatians. The final six studies deal with the importance of Philo's writings for the interpretation (...) of the Revelation of John, a subject too rarely touched upon in recent scholarship. (shrink)

Goethe's objections to Newton's theory of light and colours are better than often acknowledged. You can accept the most important elements of these objections without disagreeing with Newton about light and colours. As I will argue, Goethe exposed a crucial weakness of Newton's methodological self-assessment. Newton believed that with the help of his prism experiments, he could prove that sunlight was composed of variously coloured rays of light. Goethe showed that this step from observation to theory is more problematic than (...) Newton wanted to admit. By insisting that the step to theory is not forced upon us by the phenomena, Goethe revealed our own free, creative contribution to theory construction. And Goethe's insight is surprisingly significant, because he correctly claimed that all of the results of Newton's prism experiments fit a theoretical alternative equally well. If this is correct, then by suggesting an alternative to a well-established physical theory, Goethe developed the problem of underdete... (shrink)

Pazifisten und deren Gegner streiten sich meist nicht bloss über moralische, sondern auch über faktisch-deskriptive Fragen. Zum Beispiel sind beide Seiten bei der Kosovo-Krise (1998/9) zu völlig entgegengesetzten Beschreibungen gekommen. Laut meiner Rekonstruktion des Pazifismus ist das keine Überraschung, weil der Pazifist die Fakten legitimerweise im Lichte seines Systems von Werten betrachtet. Seine Gegnerin betrachtet die Fakten dagegen im Lichte eines alternativen Wertsystems, und der Streit zwischen den beiden Parteien, der sich angeblich auf wertfrei deskriptivem Boden bewegt, kommt zu keinem (...) Ende, weil es keine objektiven Tatsachen aus dem betreffenden Krieg gibt, die den Streit für die eine oder die andere Seite eindeutig entscheiden könnten. Wenn ich recht habe, lässt sich die wertbeladene Weltsicht des Pazifisten als eine Befolgung dreier epistemischer Imperative verstehen: Erstens befolgt er den epistemischen Imperativ zur Natur des Menschen ("Wehre Dich gegen Dämonisierungen der Gegenseite; versuche immer, den Fall aus der Sicht der Gegenseite zu verstehen"). Zweitens befolgt er den epistemischen Imperativ zugunsten friedfertiger Alternativen ("Suche immer nach friedfertigen Alternativen zum geplanten Militäreinsatz"). Und drittens befolgt er den epistemischen Imperativ bezüglich unkontrollierbarer Eskalation ("Schärfe deinen Blick für unkontrollierbare, irreversible Nebenfolgen des militärischen Einsatzes, und achte besonders auf die Gefahr, dass ein weiterer Weltkrieg ausbrechen könnte"). Nicht die objektive Realität entscheidet darüber, wie weit man bei der Befolgung dieser Imperative gehen sollte. Die Entscheidung hängt vielmehr von uns selbst ab – so ähnlich wie im Fall einer Naturwissenschaftlerin, die sich dafür entscheidet, hinter dem Chaos des Mannigfaltigen noch nach einer gemeinsamen Tiefenstruktur zu suchen. Diese Parallele hat eine überraschende Konsequenz. Die epistemischen Imperative des Pazifisten können mit Kants regulativen Prinzipien verglichen werden, die laut Kant notwendig sind, um unseren naturwissenschaftlichen Untersuchungen eine Orientierung zu geben. Und wenn sich also die Erkenntnismethode des Pazifisten in entscheidender Hinsicht nicht von der naturwissenschaftlichen Erkenntnismethode unterscheidet, dann verdienen die Pazifisten einen Vorwurf ganz sicher nicht: den Vorwurf, auf irrationale Weise blind zu sein für die harten Wirklichkeiten. Selbst wer den Pazifismus ablehnt, sollte ihm nicht den intellektuellen Respekt verweigern. Dass der Pazifismus in der Tat eine attraktive Position darstellt, werde ich am Ende meiner Überlegungen plausibel zu machen versuchen. (shrink)